Effects of raw material homogenization on the structure of basalt melt and performance of fibers

In this study, basalt from a base in Hebei, China, was selected as the raw material. Water-quenched basalt glasses and basalt fibers were prepared at different homogenization times and temperatures. The water-quenched glass structure was characterized by XRD and a Raman spectrometer followed by fitting of their Raman spectra by Gaussian curves to obtain information about melt structure. The fiber performance was characterized by fiber strength meter and fiber fineness meter. The results demonstrate that homogenization time and temperature had significant effects on the structure of basalt melt. The degree of polymerization of the melt increased with increasing homogenization time and decreased with increasing homogenization temperature. The fiber strength increased with increasing the degree of polymerization. As the homogenization time and temperature increased, coefficients of variation of fiber strength and fiber diameter decreased, indicating enhanced fiber stability.     

Preparation and properties of AZO/PS/AZO tri-layer transparent conductive film with a light-trapping structure

The light-trapping structure is an effective method to increase solar light capture efficiency in the solar cells. In this study, Al-doped ZnO (AZO)/polystyrene (PS)/AZO tri-layer transparent conductive film with light-trapping structure was fabricated by magnetron sputtering and liquid phase methods. The structural, optical and electrical properties of the AZO films could be controlled by different growth conditions. When the sputtering pressure of the under-layer AZO film was 0.2 Pa, the discharge voltage was around 80 V, which was within the optimal process window for obtaining AZO film with high crystallinity. The optimal under-layer AZO film had a large surface roughness and a very low static water contact angle of 75.71°, promoting the relatively uniform distribution of PS spheres. Under this sputtering condition, the prepared AZO/PS/AZO tri-layer film had the highest crystallinity and least point defects. The highest carrier concentration and Hall mobility are 3.0 × 10²¹ cm^-3and 5.39 cm² V^-1 s^-1, respectively. Additionally, a transparent conductive film with the lowest resistivity value (3.88 × 10^-4 Ω cm) and the highest average haze value (26.5%) was obtained by optimizing the process parameters. These properties were comparable to or exceed the reported values of surface-textured SnO₂-based as well as ZnO-based TCOs films, making our films suitable for transparent electrode applications, especially in thin-film solar cells.     

对大中型钢结构企业生产管理体系的研究分析

以某大型钢结构制造企业为例,通过对产量分布、质量控制、劳动效率等基本数据的分析,研判外协生产管理体系方面存在的问题,从组织形态、管理模式、职能管理等多个维度提出了可行性建议,可为同类型钢结构制造企业提供经验借鉴。     

From Oxadiazole to Triazole Analogues: Optimization toward a Dual Orexin Receptor Antagonist with Improved in vivo Efficacy in Dogs

The orexin system is responsible for regulating the sleep-wake cycle. Suvorexant, a dual orexin receptor antagonist (DORA) is approved by the FDA for the treatment of insomnia disorders. Herein, we report the optimization efforts toward a DORA, where our starting point was (5-methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}methanone ( 6 ), a compound which emerged from our in-house research program. Compound 6 was shown to be a potent, brain-penetrating DORA with in vivo efficacy similar to suvorexant in rats. However, shortcomings from low metabolic stability, high plasma protein binding (PPB), low brain free fraction (f_u brain), and low aqueous solubility, were identified and hence, compound 6 was not an ideal candidate for further development. Our optimization efforts addressing the above-mentioned shortcomings resulted in the identification of (4-chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-methyl-2-[5-(2-trifluoromethoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}l-methanone ( 42 ), a DORA with improved in vivo efficacy compared to 6 .     

碱铝硅酸盐玻璃化学强化关键影响因素概述

化学强化是一种玻璃机械强度增强方法,适用于异型、超薄、高碱、高膨胀玻璃增强,因新型超薄显示产品的屏幕保护玻璃发展需要,化学强化技术重新在碱铝硅酸盐玻璃品种掀起研究热潮。本文对化学强化本质及铝硅酸盐玻璃在屏幕保护玻璃应用进行了回顾,基于玻璃化学强化的高CS、DOL和低CT诉求,归纳总结了关键影响因素,第1,碱铝硅酸盐玻璃的成分及结构是基础,氧化铝有利玻璃网络孔隙增大创造交换通道,氧化钠或氧化锂是离子交换关键物质;第2,对于玻璃组成和结构设计,要求玻璃网络键合度R=O/Si或O/(Si+Al)满足2.15~2.40,碱金属氧化物质量分数大于13%且膨胀系数大于6×10^-6/℃;第3,在化学强化工艺方面,化学强化温度决定离子扩散系数,化学强化时间决定DOL,一步法仅能获得相对较大的CS,而DOL不很理想,只有两种离子参与交换的二步法才有利于CS和DOL同步提高。     

Morpholine As a Scaffold in Medicinal Chemistry: An Update on Synthetic Strategies

Morpholine is a frequently used heterocycle in medicinal chemistry and a privileged structural component of bioactive molecules. This is mainly due to its contribution to a plethora of biological activities as well as to an improved pharmacokinetic profile of such bioactive molecules. The synthesis of morpholines is a subject of much study due to their biological and pharmacological importance, with the last such review being published in 2013. Here, an overview of the main approaches toward morpholine synthesis or functionalization is presented, emphasizing on novel work which has not been reviewed so far. This review is an update on synthetic strategies leading to easily accessible libraries of bioactives which are of interest for drug discovery projects.     

Design,Synthesis, and in vitro Evaluation of P2X7 Antagonists

The P2X7 receptor is a promising target for the treatment of various diseases due to its significant role in inflammation and immune cell signaling. This work describes the design, synthesis, and in vitro evaluation of a series of novel derivatives bearing diverse scaffolds as potent P2X7 antagonists. Our approach was based on structural modifications of reported (adamantan-1-yl)methylbenzamides able to inhibit the receptor activation. The adamantane moieties and the amide bond were replaced, and the replacements were evaluated by a ligand-based pharmacophore model. The antagonistic potency of the synthesized analogues was assessed by two-electrode voltage clamp experiments, using Xenopus laevis oocytes that express the human P2X7 receptor. SAR studies suggested that the replacement of the adamantane ring by an aryl-cyclohexyl moiety afforded the most potent antagonists against the activation of the P2X7 cation channel, with analogue 2-chloro-N-[1-(3-(nitrooxymethyl)phenyl)cyclohexyl)methyl]benzamide ( 56 ) exhibiting the best potency with an IC₅₀ value of 0.39 μM.     

井下作业面巷道切顶卸压施工设计探究

以井下作业面巷道切顶卸压施工设计为对象开展探究,结合具体工程实际,从切顶卸压爆破施工设计和爆破施工分析两个角度,对切顶卸压技术的全面应用进行总结分析,希望能够为其他矿井相似工程的开展提供借鉴与参考。     

渐变刚度板簧式轻卡悬架阻尼参数仿真设计

为了有效提高渐变刚度钢板弹簧式轻型卡车的乘坐舒适性,根据弹簧受力与刚度和变形之间的关系,利用等频原理,建立了渐变刚度钢板弹簧力学特性解析计算模型,并利用钢板弹簧加载-卸载试验对所建立的模型的正确性进行了验证。基于1/2车辆行驶振动模型,利用MATLAB的Simulink工具箱,建立了考虑渐变刚度钢板弹簧力学特性的轻卡行驶振动仿真分析模型。最后,以人体振动舒适性最佳为目标,利用多岛遗传算法,建立了轻卡悬架系统阻尼参数仿真设计方法,并利用实车试验对所建立的轻卡悬架系统阻尼参数仿真设计方法的正确性进行了验证。上述研究为渐变刚度钢板弹簧式轻卡悬架系统参数的设计提供了有效参考。     

以 提高实践能力为目标的数据结构课程教学改革探索

This paper analyzes the problems existing in the teaching of data structure course, and puts forward the reform from the as- pects of strengthening basic programming, visualized explanation of abstract theory, combination of C++, Java programming, ratio- nal use of online platform, and stratification of exercises, aiming at improving students' practical ability, learning interest and self- confidence.